Hydrogen sulfide promotes angiogenesis 1 by down - regulating miR - 640 2 via the VEGFR 2 / mTOR pathway 3 4
نویسندگان
چکیده
1 Research Center on Aging and Medicine, Fudan University, Shanghai Key 9 Laboratory of Bioactive Small Molecules, Department of Physiology and 10 Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China 11 2 Department of Physiology, Hainan Medical College, Haikou, Hainan 571101, China 12 3 Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, 13 China 14 † These authors contributed equally in this study 15 16 Running title: miR-640 mediates the proangiogenic role of H2S 17 18 *Corresponding author: Prof. Yi-Chun Zhu 19 Address: Department of Physiology and Pathophysiology, Fudan University Shanghai 20 Medical College, 138 Yi Xue Yuan Road Shanghai 200032, China 21 Tel: +086 21 5423 7098; fax: +86 21 5423 7098 22 E-mail address: [email protected] (Y. C. Zhu) 23 24 25 Word count: 4203 (excluding references and figure legends) 26 Number of figures: 8 27 28 Articles in PresS. Am J Physiol Cell Physiol (November 25, 2015). doi:10.1152/ajpcell.00230.2015
منابع مشابه
Hydrogen sulfide promotes angiogenesis by downregulating miR-640 via the VEGFR2/mTOR pathway.
We previously found hydrogen sulfide (H2S) to be a new proangiogenic factor. However, the mechanisms underlying the cardiovascular effect of this small gas molecule remain largely unknown. The aim of the present study was to identify the essential microRNAs (miRNAs) involved in the transduction of H2S signals in vascular endothelial cells (ECs). The expression of miR-640 and its signaling eleme...
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